Property Summary

NCBI Gene PubMed Count 11
PubMed Score 171.03
PubTator Score 52.35

Knowledge Summary

Patent (9,059)

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
astrocytoma 1493 3.70038013302825E-15
ovarian cancer 8492 3.0602145741251E-7
Pick disease 1893 8.0471391208924E-6
malignant mesothelioma 3163 1.6821219321554E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 3.09369598525415E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.92986322383614E-5
psoriasis 6685 2.02032839909454E-4
interstitial cystitis 2299 4.76046977453785E-4
primitive neuroectodermal tumor 3031 0.00132067458711894
osteosarcoma 7933 0.00219515332956612
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00538388126742483
oligodendroglioma 2849 0.00939371123237799
group 3 medulloblastoma 2254 0.0189376254284789
gastric carcinoma 832 0.0386113756762404

Expression

  Differential Expression (14)

Gene

PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG
Xenopus OMA EggNOG Inparanoid

  TechDev Info (2)

Bryan Roth functional assay
Steve Finkbeiner Neuron specific phenotypes being screened

Gene RIF (5)

PMID Text
27002170 Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
24599592 G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
19536175 Observational study of gene-disease association. (HuGE Navigator)
19064610 Observational study of gene-disease association. (HuGE Navigator)
11959142 False positive non-synonymous polymorphisms of G-protein coupled receptor genes.

AA Sequence

MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLT      1 - 70
LSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKIT     71 - 140
GNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGF    141 - 210
IFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFM    211 - 280
VTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFV    281 - 350
QRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH    351 - 420
CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVT    421 - 490
ARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR                                   491 - 529
//

Text Mined References (11)

PMID Year Title
27002170 2016 Smoothened determines ?-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
24599592 2014 G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
19536175 2009 Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
19064610 2009 Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
18250320 2008 The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11987825 2002 The structural basis of G-protein-coupled receptor function and dysfunction in human diseases.
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