Tbio | EP300-interacting inhibitor of differentiation 2 |
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
Comments
Disease | Target Count | P-value |
---|---|---|
oligodendroglioma | 2849 | 0.0275414877810761 |
astrocytic glioma | 2241 | 0.0301892534101549 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Salpingitis | 6 | 3.472 | 1.7 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -1.200 | 0.030 |
oligodendroglioma | -1.300 | 0.028 |
PMID | Text |
---|---|
14612439 | EID-2 may function as an endogenous suppressor of TGF-beta signaling |
PMID | Year | Title |
---|---|---|
24129315 | 2014 | Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
15970276 | 2005 | A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
14612439 | 2004 | A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes. |
14585496 | 2003 | EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. |
12586827 | 2003 | A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |