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Tbio EP300-interacting inhibitor of differentiation 2

Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

 Comments

Property Summary

NCBI Gene PubMed Count 5
Grant Count 1
Funding $16,822.5
PubMed Score 20.29
PubTator Score 20.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (3)

Disease Z-score Confidence
Salpingitis 6 3.472 1.7
astrocytic glioma 2,241
oligodendroglioma 2,849

Expression

  Differential Expression (2)

Disease log2 FC p
astrocytic glioma -1.200 0.030
oligodendroglioma -1.300 0.028

Synonym

Accession Q8N6I1 A7YQ71 Q6X7T0 Q6ZR61 EID-2
Symbols CRI2
EID-2

Gene

EID2

 Grant Application (1)

 GO Function (1)

 GO Component (2)

 GO Process (10)

 Compartment GO Term (20)

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Pathway (2)

 UniProt Keyword (13)

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Gene RIF (1)

PMID Text
14612439 EID-2 may function as an endogenous suppressor of TGF-beta signaling

AA Sequence 

MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAP      1 - 70
AAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYL     71 - 140
RLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTF    141 - 210
TIALTASEVINPLIEELGCDKFINRE                                                211 - 236
//

Text Mined References (9)

PMID Year Title
24129315 2014 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
15970276 2005 A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14612439 2004 A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes.
14585496 2003 EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD.
12586827 2003 A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.