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Tbio EP300-interacting inhibitor of differentiation 2

Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 21.13
PubTator Score 20.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
oligodendroglioma 2850 2.8e-02
astrocytic glioma 2597 3.0e-02
Disease Target Count Z-score Confidence
Salpingitis 6 3.425 1.7

Expression

  Differential Expression (2)

Disease log2 FC p
astrocytic glioma -1.200 3.0e-02
oligodendroglioma -1.300 2.8e-02

Synonym

Accession Q8N6I1 A7YQ71 Q6X7T0 Q6ZR61 EID-2
Symbols CRI2
EID-2

Gene

EID2

  Ortholog (7)

Species Source Disease
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG

 UniProt Keyword (13)

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 GO Function (1)

 GO Component (2)

 GO Process (10)

 Compartment GO Term (20)

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 HCA RNA Cell Line (56)

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Pathway (2)

Gene RIF (1)

AA Sequence 

MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAP      1 - 70
AAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYL     71 - 140
RLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTF    141 - 210
TIALTASEVINPLIEELGCDKFINRE                                                211 - 236
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Text Mined References (9)

PMID Year Title