Tbio SLC5A8 Sodium-coupled monocarboxylate transporter 1

Protein Summary

Description

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

Uniprot Accession IDs

• Q8N695
• Q2TB99
• Q7Z2H9

Gene Name

• SLC5A8

Ensembl ID

• ENST00000536262
• ENSP00000445340
• ENSG00000256870
• ENST00000572861
• ENSP00000461697
• ENSG00000262217

Symbol

• AIT
• SMCT
• SMCT1
• AIT
• SMCT
• SMCT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
cell type or tissue	0.84
cell line	0.58
PubMedID	0.54
biological term	0.53

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-coupled Monocarboxylate Transporter 1

Protein / Transporter / Carbohydrate Transporter / Sodium-coupled Monocarboxylate Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc5 Family Of Sodium-dependent Glucose Transporters / Sodium Iodide Symporter, Sodium-dependent Multivitamin Transporter And Sodium-coupled Monocarboxylate Transporters / Sodium-coupled Monocarboxylate Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.99   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.99   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3