| Tbio | Mono [ADP-ribose] polymerase PARP16 |
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
Comments
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKE 1 - 70 LLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYE 71 - 140 TKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILS 141 - 210 CVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRAS 211 - 280 SQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR 281 - 322 //
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25037261 | 2015 | Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-?1 mono-ADP-ribosylation by ARTD15. |
| 23103912 | 2012 | PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1?-mediated unfolded protein response. |
| 22701565 | 2012 | PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. |
| 22661712 | 2012 | Crystal structure of human ADP-ribose transferase ARTD15/PARP16 reveals a novel putative regulatory domain. |
| 20106667 | 2010 | Toward a unified nomenclature for mammalian ADP-ribosyltransferases. |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15273990 | 2004 | The PARP superfamily. |
| More... |
