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Tbio
ZC3H8
Zinc finger CCCH domain-containing protein 8

Protein Summary
Description
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272570
  • ENSP00000272570
  • ENSG00000144161
  • ENST00000409573
  • ENSP00000386488

Symbol
  • ZC3HDC8
  • Fliz1
  • ZC3HDC8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
histone modification site profile
0.73
cell type or tissue
0.72
transcription factor binding site profile
0.71
cellular component
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0