Tbio KCNRG Potassium channel regulatory protein

Protein Summary

Description

Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8N5I3
• A2A2X9
• Q0P6D0
• Q8IU75
• Q8N3Q9
• Potassium channel regulator

Gene Name

• KCNRG

Ensembl ID

• ENST00000312942
• ENSP00000324191
• ENSG00000198553
• ENST00000360473
• ENSP00000353661

Symbol

• CLLD4
• DLTET

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.53
tissue	0.5
cell line	0.48
protein complex	0.45
cellular component	0.43

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Potassium Channel Regulatory Protein

DTO Classes

Protein / Enzyme Modulator / Potassium Channel Regulatory Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0