| Tchem | Serine/threonine-protein kinase DCLK2 |
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.0055614699918335 |
| oligodendroglioma | 2849 | 0.00746385912258289 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.0126013606992847 |
| astrocytic glioma | 2241 | 0.0245580792221703 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lissencephaly | 61 | 3.425 | 1.7 |
| Quadriplegia | 14 | 3.065 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.100 | 0.025 |
| oligodendroglioma | 1.100 | 0.007 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 0.006 |
| intraductal papillary-mucinous carcinoma... | -1.100 | 0.013 |
| Species | Source |
|---|---|
| Macaque | OMA Inparanoid |
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Platypus | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| C. elegans | OMA Inparanoid |
| Fruitfly | OMA Inparanoid |
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKK 1 - 70 AKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLE 71 - 140 GESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRK 141 - 210 AVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDD 211 - 280 FVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRG 281 - 350 LKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF 351 - 420 ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTER 421 - 490 DGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAP 491 - 560 EIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQ 561 - 630 MLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQ 631 - 700 IFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD 701 - 766 //
| PMID | Year | Title |
|---|---|---|
| 25512093 | 2015 | Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies. |
| 24133439 | 2013 | Genome-wide association study of autistic-like traits in a general population study of young adults. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22589738 | 2012 | Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. |
| 20236041 | 2010 | The doublecortin gene family and disorders of neuronal structure. |
| 19342486 | 2009 | Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. |
| 18618084 | 2008 | Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene. |
| 18075264 | 2008 | Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 17344846 | 2007 | Patterns of somatic mutation in human cancer genomes. |
| More... |
