Tbio CBR4 Carbonyl reductase family member 4

Protein Summary

Description

The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).

Uniprot Accession IDs

• Q8N4T8
• Q8WTW8
• Q96K93

Gene Name

• CBR4

Ensembl ID

• ENST00000306193
• ENSP00000303525
• ENSG00000145439
• ENST00000504480
• ENSP00000427615

Symbol

• SDR45C1
• SDR45C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
disease perturbation	0.83
molecular function	0.73
tissue sample	0.68
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Carbonyl Reductase Family Member 4

Protein / Oxidoreductase / Dehydrogenase / Carbonyl Reductase Family Member 4

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Carbonyl Reductase Family Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0