Property Summary

NCBI Gene PubMed Count 34
PubMed Score 11.30
PubTator Score 38.75

Knowledge Summary


No data available


  Disease Sources (3)

Gene RIF (27)

23573868 experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
22706241 FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
21799823 MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
21712541 Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.
21616139 higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc
20939738 The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease.
20939738 Observational study of gene-disease association. (HuGE Navigator)
20877624 Observational study of gene-disease association. (HuGE Navigator)
20526373 Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin.
20369475 MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 and upregulation of Fn.

AA Sequence

HVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN                                          211 - 242

Text Mined References (34)

PMID Year Title
25140149 2014 Genetic variation modifies risk for neurodegeneration based on biomarker status.
25133637 2014 Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
23897914 2013 A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
23573868 2013 Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors.
22706241 2012 Study of FTMT and ABCA4 genes in a patient affected by age-related macular degeneration: identification and analysis of new mutations.
21799823 2011 Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.
21712541 2011 Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.
21630459 2011 Proteomic characterization of the human sperm nucleus.
21616139 2011 P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.
20939738 2010 Sequence variations in mitochondrial ferritin: distribution in healthy controls and different types of patients.