Tchem MINK1 Misshapen-like kinase 1

Protein Summary

Description

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q8N4C8
• D3DTK3
• D3DTK4
• Q5U8Z0
• Q9P1X1
• Q9P2R8

Gene Name

• MINK1

Ensembl ID

• ENST00000347992
• ENSP00000269296
• ENSG00000141503
• ENST00000355280
• ENSP00000347427
• ENST00000453408
• ENSP00000406487

Symbol

• B55
• MAP4K6
• MINK
• YSK2
• ZC3
• B55
• ZC3
• MINK
• YSK2
• MAP4K6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
small molecule	0.92
transcription factor perturbation	0.88
protein domain	0.85
kinase perturbation	0.84

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Msn Subfamily / Misshapen-like Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.85   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.85   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3