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Tchem
MINK1
Misshapen-like kinase 1

Protein Summary
Description
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347992
  • ENSP00000269296
  • ENSG00000141503
  • ENST00000355280
  • ENSP00000347427
  • ENST00000453408
  • ENSP00000406487

Symbol
  • B55
  • MAP4K6
  • MINK
  • YSK2
  • ZC3
  • B55
  • ZC3
  • MINK
  • YSK2
  • MAP4K6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
small molecule
0.92
transcription factor perturbation
0.88
protein domain
0.85
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.85   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3