Property Summary

NCBI Gene PubMed Count 14
PubMed Score 21.46
PubTator Score 10.28

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung adenocarcinoma 2714 1.59339871307095E-12
osteosarcoma 7933 2.77053108426535E-6
glioblastoma 5572 7.71975691879119E-5
medulloblastoma, large-cell 6234 7.5784915845379E-4
invasive ductal carcinoma 2950 0.00106933398240001
ovarian cancer 8492 0.00159307066369715
spina bifida 1064 0.0380796604045086
Disease Target Count Z-score Confidence
Q fever 11 3.16 1.6

Expression

  Differential Expression (7)

Disease log2 FC p
osteosarcoma -1.731 0.000
glioblastoma -1.200 0.000
medulloblastoma, large-cell -1.300 0.001
lung adenocarcinoma -1.200 0.000
spina bifida -1.889 0.038
invasive ductal carcinoma 1.100 0.001
ovarian cancer 1.100 0.002

Synonym

Accession Q8N448 Q5W0P0 Q6ZMH2 Q96SH4
Symbols PDZRN1

Gene

PDB

2VWR   5DIN  

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA EggNOG Inparanoid

 GO Function (1)

 Compartment GO Term (2)

Gene RIF (4)

PMID Text
23319804 FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors
22066909 The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever.
22045731 LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis
18187620 Knockdown of ligand of numb-protein X 2 (LNX2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells

AA Sequence

MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFC      1 - 70
YKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKNRCPGA     71 - 140
SHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPA    141 - 210
FEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAG    211 - 280
DQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQ    281 - 350
LGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR    351 - 420
PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSK    421 - 490
SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEE    491 - 560
ATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFI    561 - 630
KTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV              631 - 690
//

Text Mined References (15)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
24483146 2014 Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
23319804 2013 Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/?-catenin pathway in colorectal cancer.
23088713 2012 Protein interactions of the transcription factor Hoxa1.
22458338 2012 Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
22066909 2012 The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.
22045731 2011 Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8? and promote its ubiquitylation and endocytosis.
21471979 2011 Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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