Tbio GUF1 Translation factor GUF1, mitochondrial

Protein Summary

Description

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8N442
• Q5XKM8
• Q9H710
• Q9H8U4

Gene Name

• GUF1

Ensembl ID

• ENST00000281543
• ENSP00000281543
• ENSG00000151806

Symbol

• EF4
• EF-4
• EIEE40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.94
virus perturbation	0.85
histone modification site profile	0.82
interacting protein	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Translation Factor Guf1, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Translation Factor Guf1, Mitochondrial

Protein / Hydrolase / Translation Factor Guf1, Mitochondrial

Protein / Enzyme Modulator / G-protein / Translation Factor Guf1, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Translation Factor Guf1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.28   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.28   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0