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Tbio
GALNT15
Polypeptide N-acetylgalactosaminyltransferase 15

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339732
  • ENSP00000344260
  • ENSG00000131386

Symbol
  • GALNTL2
  • PIH5
  • GALNT7
  • GALNT13
  • GALNTL2
  • GALNACT15
  • pp-GalNAc-T15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.68
cellular component
0.6
tissue
0.56
kinase perturbation
0.54
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0