Tbio CMYA5 Cardiomyopathy-associated protein 5

Protein Summary

Description

May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity).

Uniprot Accession IDs

• Q8N3K9
• A0PJB7
• Q05CT4
• Q2NKX1
• Q2T9G9
• Q69YQ8
• Q69YQ9
• Q6P517
• Q6P5U3
• Q7Z4I1
• Q86T34
• Q86T49
• Q8N3S4
• Q8N3S7
• Q8NAG8
• Q9UK88

Gene Name

• CMYA5

Ensembl ID

• ENST00000446378
• ENSP00000394770
• ENSG00000164309

Symbol

• C5orf10
• DTNBP2
• SPRYD2
• TRIM76
• SPRYD2
• TRIM76
• C5orf10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
protein domain	0.73
histone modification site profile	0.63
phenotype	0.53
cell line	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.65   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.65   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0