PPM1K
Protein phosphatase 1K, mitochondrial
Protein Summary
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
- ENST00000608933
- ENSP00000477341
- ENSG00000163644
- PP2CM
- BDP
- PTMP
- PP2Cm
- MSUDMV
- PP2Ckappa
- UG0882E07
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.75 | ||
microRNA | 0.69 | ||
tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.55 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.55 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0