| Tdark | Protein FAM19A2 |
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Chronic Obstructive Airway Disease | 47 |
| Obesity | 616 |
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2849 | 3.39184308160978E-14 |
| posterior fossa group A ependymoma | 1511 | 2.36119651236679E-10 |
| pituitary cancer | 1972 | 6.27889614184385E-6 |
| glioblastoma | 5572 | 2.79274667147893E-5 |
| interstitial cystitis | 2299 | 3.93367680090789E-5 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.00900348982027E-5 |
| adult high grade glioma | 2148 | 3.29121649013704E-4 |
| osteosarcoma | 7933 | 4.23893663057768E-4 |
| medulloblastoma | 1524 | 9.92637536047417E-4 |
| astrocytic glioma | 2241 | 0.00119252358980339 |
| pilocytic astrocytoma | 3086 | 0.0013003565133655 |
| primitive neuroectodermal tumor | 3031 | 0.00176408404220364 |
| medulloblastoma, large-cell | 6234 | 0.00222580442787948 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cornelia de Lange syndrome | 21 | 3.814 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -2.700 | 0.001 |
| posterior fossa group A ependymoma | -3.200 | 0.000 |
| oligodendroglioma | -2.300 | 0.000 |
| glioblastoma | -3.900 | 0.000 |
| osteosarcoma | -2.204 | 0.000 |
| medulloblastoma | -2.900 | 0.001 |
| atypical teratoid / rhabdoid tumor | -3.100 | 0.000 |
| medulloblastoma, large-cell | -3.600 | 0.002 |
| primitive neuroectodermal tumor | -2.800 | 0.002 |
| interstitial cystitis | -2.800 | 0.000 |
| adult high grade glioma | -3.400 | 0.000 |
| pilocytic astrocytoma | -2.000 | 0.001 |
| pituitary cancer | -2.300 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG |
| Platypus | OMA EggNOG |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| PMID | Year | Title |
|---|---|---|
| 25112515 | 2014 | Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. |
| 24621683 | 2014 | Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. |
| 24554482 | 2014 | Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. |
| 24388013 | 2014 | Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. |
| 23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| 21348951 | 2011 | Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19240061 | 2009 | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
