Tbio ARMC10 Armadillo repeat-containing protein 10

Protein Summary

Description

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8N2F6
• A8K703
• B4DWJ8
• F5GX65
• Q75K91
• Q75MG6
• Q75ML8
• Q8IZC1
• Q8IZC2
• Q8IZC3
• Q9BTM6

Gene Name

• ARMC10

Ensembl ID

• ENST00000323716
• ENSP00000319412
• ENSG00000170632
• ENST00000425331
• ENSP00000397969
• ENST00000428183
• ENSP00000396654
• ENST00000441711
• ENSP00000413619
• ENST00000454559
• ENSP00000405612
• ENST00000541300
• ENSP00000440463

Symbol

• SVH
• SVH
• PNAS112
• PNAS-112
• PSEC0198

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.96
disease perturbation	0.87
histone modification site profile	0.85
transcription factor binding site profile	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.99   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.99   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0