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Tbio
LILRA2
Leukocyte immunoglobulin-like receptor subfamily A member 2

Protein Summary
Description
Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251376
  • ENSP00000251376
  • ENSG00000239998
  • ENST00000251377
  • ENSP00000251377
  • ENST00000391738
  • ENSP00000375618
  • ENST00000611940
  • ENSP00000478981
  • ENSG00000275290
  • ENST00000613573
  • ENSP00000479743
  • ENST00000616629
  • ENSP00000481338
  • ENST00000617409
  • ENSP00000479914
  • ENSG00000274000
  • ENST00000620279
  • ENSP00000480939
  • ENST00000621721
  • ENSP00000484762
  • ENSG00000278634
  • ENST00000622640
  • ENSP00000483906

Symbol
  • ILT1
  • LIR7
  • ILT1
  • LIR7
  • CD85H
  • LIR-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
kinase perturbation
0.66
cell type or tissue
0.58
protein domain
0.58
tissue
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0