Tdark ZNF444 Zinc finger protein 444

Protein Summary

Description

Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q8N0Y2
• Q8TEQ9
• Q8WU35
• Q9NUU1

Gene Name

• ZNF444

Ensembl ID

• ENST00000337080
• ENSP00000338860
• ENSG00000167685
• ENST00000592949
• ENSP00000468069

Symbol

• EZF2
• ZSCAN17
• EZF2
• EZF-2
• ZSCAN17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.76
transcription factor binding site profile	0.74
cell type or tissue	0.67
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.73   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.73   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0