| Tdark | WD repeat-containing protein 17 |
This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
Comments
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | -1.400 | 0.000 |
| glioblastoma | -2.000 | 0.005 |
| oligodendroglioma | -1.300 | 0.000 |
| group 3 medulloblastoma | -1.600 | 0.045 |
| medulloblastoma, large-cell | -1.800 | 0.004 |
| lung adenocarcinoma | -1.300 | 0.000 |
| pediatric high grade glioma | -1.100 | 0.041 |
| lung carcinoma | 2.100 | 0.000 |
| non-small cell lung carcinoma | -1.300 | 0.000 |
| Breast cancer | -1.500 | 0.000 |
| ovarian cancer | -2.100 | 0.000 |
| PMID | Text |
|---|---|
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 19727342 | Strong candidate gene for retinitis pigmentosa, RP29 (human 4q32-q34). Conclusion is based on a massive expression data set for mouse (103 strains) and joint analysis of RetNet database. |
| 12401215 | cloning and characterization of gene which represents a new member of the WD repeat family abundant in retina and testis |
MAWMTYISNWFEQDDWYEGLQRANMSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRY 1 - 70 NEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAED 71 - 140 VVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPGNKNQKH 141 - 210 VLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSA 211 - 280 PGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPP 281 - 350 TLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKV 351 - 420 WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH 421 - 490 KDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLK 491 - 560 VFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSW 561 - 630 DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWE 631 - 700 EIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRWFSECLSPPGGSDNLWNLVAVIKGQDD 701 - 770 SLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMSKFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMV 771 - 840 ELGEWDKALSIAPGVSVKYWKKLMQRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQ 841 - 910 AACEGNMQPLHVSVPKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYL 911 - 980 IRGNELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLLMIPDNE 981 - 1050 LHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLLSQEPEKALPIGISFVK 1051 - 1120 EYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYQSIVPALYEYTSQ 1121 - 1190 LLKRREVSVPLKIEYLSEELDAWRACTQSTNRSLEDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDY 1191 - 1260 VTGSNLPSHSDIHISCLTGLKIQGPVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF 1261 - 1322 //
| PMID | Year | Title |
|---|---|---|
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19727342 | 2009 | Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. |
| 17286855 | 2007 | Mapping of transcription start sites of human retina expressed genes. |
| 15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15342556 | 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 12401215 | 2002 | Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34. |
