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  7. WD repeat-containing protein 17

Tdark WD repeat-containing protein 17

This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 0.05
PubTator Score 2.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Liver neoplasms 109
Disease Target Count P-value
non-small cell lung carcinoma 413 2.3487289756378E-20
lung carcinoma 2844 3.27963877005752E-20
astrocytoma 1493 1.37614177322485E-12
oligodendroglioma 2849 4.88778472868116E-11
lung adenocarcinoma 2714 1.26433231780626E-9
ovarian cancer 8492 6.3230236100351E-8
Breast cancer 3099 9.56101941700104E-8
medulloblastoma, large-cell 6234 0.0044521694102251
glioblastoma 5572 0.00451769494046297
pediatric high grade glioma 2712 0.0412863908135251
group 3 medulloblastoma 2254 0.045326795728881
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (11)

Disease log2 FC p
astrocytoma -1.400 0.000
glioblastoma -2.000 0.005
oligodendroglioma -1.300 0.000
group 3 medulloblastoma -1.600 0.045
medulloblastoma, large-cell -1.800 0.004
lung adenocarcinoma -1.300 0.000
pediatric high grade glioma -1.100 0.041
lung carcinoma 2.100 0.000
non-small cell lung carcinoma -1.300 0.000
Breast cancer -1.500 0.000
ovarian cancer -2.100 0.000

Synonym

Accession Q8IZU2 E7EQX0 Q0QD35
Symbols

Gene

WDR17

PANTHER Protein Class (4)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

 Compartment GO Term (2)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

 UniProt Keyword (6)

Gene RIF (3)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19727342 Strong candidate gene for retinitis pigmentosa, RP29 (human 4q32-q34). Conclusion is based on a massive expression data set for mouse (103 strains) and joint analysis of RetNet database.
12401215 cloning and characterization of gene which represents a new member of the WD repeat family abundant in retina and testis

AA Sequence 

MAWMTYISNWFEQDDWYEGLQRANMSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRY      1 - 70
NEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAED     71 - 140
VVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPGNKNQKH    141 - 210
VLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSA    211 - 280
PGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPP    281 - 350
TLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKV    351 - 420
WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH    421 - 490
KDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLK    491 - 560
VFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSW    561 - 630
DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWE    631 - 700
EIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRWFSECLSPPGGSDNLWNLVAVIKGQDD    701 - 770
SLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMSKFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMV    771 - 840
ELGEWDKALSIAPGVSVKYWKKLMQRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQ    841 - 910
AACEGNMQPLHVSVPKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYL    911 - 980
IRGNELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLLMIPDNE    981 - 1050
LHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLLSQEPEKALPIGISFVK   1051 - 1120
EYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYQSIVPALYEYTSQ   1121 - 1190
LLKRREVSVPLKIEYLSEELDAWRACTQSTNRSLEDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDY   1191 - 1260
VTGSNLPSHSDIHISCLTGLKIQGPVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF           1261 - 1322
//

Text Mined References (8)

PMID Year Title
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19727342 2009 Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice.
17286855 2007 Mapping of transcription start sites of human retina expressed genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12401215 2002 Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34.