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Tdark WD repeat-containing protein 17

This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 0.05
PubTator Score 2.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Liver neoplasms 130 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.2
Kidney cancer 2613 0.0 0.9

Expression

  Differential Expression (11)

Disease log2 FC p
astrocytoma -1.400 1.4e-12
Breast cancer -1.500 9.6e-08
glioblastoma -2.000 4.5e-03
group 3 medulloblastoma -1.600 4.5e-02
lung adenocarcinoma -1.300 1.3e-09
lung carcinoma 2.100 3.3e-20
medulloblastoma, large-cell -1.800 4.5e-03
non-small cell lung carcinoma -1.300 2.3e-20
oligodendroglioma -1.300 4.9e-11
ovarian cancer -2.100 6.3e-08
pediatric high grade glioma -1.100 4.1e-02

Synonym

Accession Q8IZU2 E7EQX0 Q0QD35
Symbols

Gene

WDR17

  Ortholog (11)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (6)

 GO Component (1)

 Compartment GO Term (7)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Gene RIF (3)

AA Sequence 

MAWMTYISNWFEQDDWYEGLQRANMSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRY      1 - 70
NEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAED     71 - 140
VVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPGNKNQKH    141 - 210
VLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSA    211 - 280
PGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPP    281 - 350
TLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKV    351 - 420
WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH    421 - 490
KDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLK    491 - 560
VFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSW    561 - 630
DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWE    631 - 700
EIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRWFSECLSPPGGSDNLWNLVAVIKGQDD    701 - 770
SLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMSKFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMV    771 - 840
ELGEWDKALSIAPGVSVKYWKKLMQRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQ    841 - 910
AACEGNMQPLHVSVPKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYL    911 - 980
IRGNELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLLMIPDNE    981 - 1050
LHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLLSQEPEKALPIGISFVK   1051 - 1120
EYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYQSIVPALYEYTSQ   1121 - 1190
LLKRREVSVPLKIEYLSEELDAWRACTQSTNRSLEDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDY   1191 - 1260
VTGSNLPSHSDIHISCLTGLKIQGPVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF           1261 - 1322
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Text Mined References (9)

PMID Year Title