Property Summary

NCBI Gene PubMed Count 65
Grant Count 197
R01 Count 131
Funding $31,909,651.47
PubMed Score 221.07
PubTator Score 76.84

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
interstitial lung disease 1.100 0.025
cystic fibrosis -2.789 0.001
Atopic dermatitis -1.400 0.002
non-small cell lung cancer -1.636 0.000
atypical teratoid/rhabdoid tumor 1.100 0.025
sonic hedgehog group medulloblastoma 1.500 0.001
psoriasis -1.500 0.000
Endometriosis -1.440 0.020
invasive ductal carcinoma -1.200 0.038

Synonym

Accession Q8IZQ8 Q5UBU5 Q8N7Q1
Symbols MYCD

Gene

PANTHER Protein Class (1)

 GO Component (1)

Gene RIF (45)

PMID Text
26244347 Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed.
26181633 our study reveals that Ang II downregulates miR-145 to regulate Klf4 and myocardin expression in HCASMCs under high glucose conditions. Ang II plays a critical role in the regulation of miR-145 under hyperglycemic conditions
26129946 inhibition of GSK-3beta reduces myocardin transcriptional activity, suggesting a role for GSK-3beta in myocardin transcriptional activity and smooth muscle differentiation
26100622 STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF.
26077572 TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang II-induced vascular remodeling.
25614278 Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease.
25384061 TNFalpha differentially regulates myocardin expression and activity
25190111 it is probably that miR135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin
24681789 Early cardiac marker gene myocardin levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease.
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of myocardin (MYOCD) in primary human brain microvascular endothelial cells
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AA Sequence

MTLLGSEHSLLIRSKFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNSLKRKARN      1 - 70
RCNSADLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKGN     71 - 140
QVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPDAKASDTPSTGSLGTNQDLASGSENDRNDS    141 - 210
ASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPP    211 - 280
PMDSAYARLLQQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSNTPLSPVK    281 - 350
NSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSGNPVPNFGDITT    351 - 420
VTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSSSPPISPASSDLSVAGSLPDTFNDASPSFGLHPSPVH    421 - 490
VCTEESLMSSLNGGSVPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQKRNNCSEK    491 - 560
KPLPFLAASIKQEEAVSSCPFASQVPVKRQSSSSECHPPACEAAQLQPLGNAHCVESSDQTNVLSSTFLS    561 - 630
PQCSPQHSPLGAVKSPQHISLPPSPNNPHFLPSSSGAQGEGHRVSSPISSQVCTAQMAGLHSSDKVGPKF    631 - 700
SIPSPTFSKSSSAISEVTQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPRS    701 - 770
SRSPTAVLTKPSASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIGSEEPHFDGIMD    771 - 840
GFSGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPWETMEWLDLTPPNSTPGFSALTTS    841 - 910
SPSIFNIDFLDVTDLNLNSSMDLHLQQW                                              911 - 938
//

Text Mined References (67)

PMID Year Title
26244347 2015 Myocardin Family Members Drive Formation of Caveolae.
26181633 2015 Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions.
26129946 2016 Potential Role of Glycogen Synthase Kinase-3? in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells.
26100622 2015 STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin.
26077572 2015 TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang II-induced vascular remodeling.
25614278 2015 Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.
25416956 2014 A proteome-scale map of the human interactome network.
25384061 2014 Dual regulation of myocardin expression by tumor necrosis factor-? in vascular smooth muscle cells.
25190111 2014 MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin.
24681789 Early cardiac gene transcript levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease.
More...