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Tbio
ADGRG2
Adhesion G-protein coupled receptor G2

Protein Summary
Description
Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340581
  • ENSP00000344972
  • ENSG00000173698
  • ENST00000354791
  • ENSP00000346845
  • ENST00000356606
  • ENSP00000349015
  • ENST00000357544
  • ENSP00000350152
  • ENST00000357991
  • ENSP00000350680
  • ENST00000360279
  • ENSP00000353421
  • ENST00000379869
  • ENSP00000369198
  • ENST00000379873
  • ENSP00000369202
  • ENST00000379876
  • ENSP00000369205
  • ENST00000379878
  • ENSP00000369207

Symbol
  • GPR64
  • HE6
  • TM7LN2
  • HE6
  • EDDM6
  • GPR64
  • CBAVDX
  • TM7LN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.8
cell type or tissue
0.76
PubMedID
0.67
cellular component
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.49   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.49   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0