Property Summary

NCBI Gene PubMed Count 33
PubMed Score 33.68
PubTator Score 10.73

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
ovarian cancer 8492 8.47475695245727E-11
medulloblastoma, large-cell 6234 6.7774056273034E-6
adult high grade glioma 2148 0.00127730007668778
atypical teratoid / rhabdoid tumor 4369 0.00142286086473946
glioblastoma 5572 0.00417995274254616
Disease Target Count Z-score Confidence
Hepatitis C 90 3.811 1.9
Hepatitis 61 3.078 1.5

Gene RIF (29)

26353965 NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation.
26194286 Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B) and IFN-lambda4.
25355870 These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection.
24973639 this study provides evidence for potential IL-28A participation in Behcet's diseaseand its value as a therapeutic agent.
24385435 Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene.
24269996 Results showed no association between genotypes and alleles of IL28A, IL28B or IL29 polymorphisms and Hepatitis C virus infection.
23652058 IL-28 genotype was not associated with response to interferon treatment (OR for GT/GG vs. TT, 0.881 (95%CI 0.388 - 2.002); P = 0.762; OR for CT/CC vs. TT, 0.902 (95%CI 0.458 - 1.778); P = 0.766).
23207147 IFN-lambdas can also directly affect T cells through inhibition of the T helper 2 cell (Th2) responses. IFN-lambdas have varying immunomodulatory functions under different physiological conditions
22962576 Elevated expression of inflammatory cytokines (IL-5, IL-20, and IL-28A) is associated with bladder cancer development.
22891284 Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon) in response to viral stimulation.

AA Sequence


Text Mined References (36)

PMID Year Title
26353965 2015 Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.
26194286 2015 Guarding the frontiers: the biology of type III interferons.
25355870 2015 Impact and regulation of lambda interferon response in human metapneumovirus infection.
24973639 2014 Interleukin-28A promotes IFN-? production by peripheral blood mononuclear cells from patients with Behçet's disease.
24751921 2014 Interferon-? in the context of viral infections: production, response and therapeutic implications.
24385435 2014 Transcriptional regulation of IFN-? genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-?B complex.
24269996 2014 Genetic polymorphisms of the IFN? genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China.
23652058 2013 Gene polymorphisms of interleukin-28, p21-activated protein kinases 4, and response to interferon-? based therapy in Chinese patients with chronic hepatitis B.
23207147 2013 Interferon-?s: special immunomodulatory agents and potential therapeutic targets.
22962576 2012 Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A.