Property Summary

NCBI Gene PubMed Count 17
PubMed Score 35.99
PubTator Score 20.61

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 3.01198966161426E-25
ependymoma 2514 1.47286687799577E-24
ovarian cancer 8492 3.051416137738E-24
lung carcinoma 2844 3.13400157969907E-14
oligodendroglioma 2849 1.57147349304227E-12
atypical teratoid / rhabdoid tumor 4369 2.47949598533308E-9
sonic hedgehog group medulloblastoma 1482 1.06632497379358E-7
malignant mesothelioma 3163 1.12952682303822E-7
pediatric high grade glioma 2712 2.95352391337837E-7
glioblastoma 5572 5.5628816386363E-6
pilocytic astrocytoma 3086 8.23513338467752E-6
primitive neuroectodermal tumor 3031 3.94801913106179E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.23164147860308E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.39942247198286E-4
lung cancer 4473 9.36654521468772E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00265107249563444
astrocytic glioma 2241 0.00658226625974421
medulloblastoma, large-cell 6234 0.0131017149396347
Pick disease 1893 0.0149260631525639
subependymal giant cell astrocytoma 2287 0.0290186955762651

Expression

Synonym

Accession Q8IYB4 B7Z2A5 B7Z305 B7Z318 B7Z5Z5 B7Z8P2 E7EUV8 E7EUZ0 E9PEC1 E9PH97 Q9NQD1 Q9P2U3 Q9P2U4
Symbols PXR2
PEX5R
PXR2B
PEX5RP
TRIP8b

Gene

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
C. elegans EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

Gene RIF (8)

PMID Text
25538232 the sequential formation of a highly stable trimeric complex involving cargo protein, PEX7 and PEX5L stabilizes cargo binding and is a prerequisite for PTS2-mediated peroxisomal import.
25197093 Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
24451387 Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
23077068 Seizure-dependent plasticity wound is not conditional upon TRIP8b in cerebral cortex.
22550182 TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression level and cyclic nucleotide dependence.
21504900 increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19460752 Knockdown of peroxisomal biogenesis factor 5-like (PEX5L; PXR2B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells

AA Sequence

MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNE      1 - 70
QQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSEPSSKTSSLKKK     71 - 140
ADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLW    141 - 210
SSEHRSQPELSGGKSALNSESASELELVAPTQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFW    211 - 280
DKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFME    281 - 350
AAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNW    351 - 420
IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF    421 - 490
NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYRE    491 - 560
AVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP        561 - 626
//

Text Mined References (20)

PMID Year Title
25538232 2015 Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.
25197093 2014 Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
24816252 2014 An atlas of genetic influences on human blood metabolites.
24451387 2014 Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
23382219 2013 Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
23077068 2012 TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
22550182 2012 Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
21504900 2011 Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.
21490949 2011 Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
More...