Property Summary

NCBI Gene PubMed Count 22
PubMed Score 17.23
PubTator Score 16.38

Knowledge Summary


No data available


  Disease Sources (6)

Disease Target Count P-value
breast carcinoma 1614 8.35187157407385E-25
lung adenocarcinoma 2714 1.1306371180272E-14
lung carcinoma 2844 8.00013185265279E-13
non-small cell lung cancer 2798 2.11539246008216E-11
posterior fossa group A ependymoma 1511 1.55433351214786E-9
Breast cancer 3099 4.10040492969678E-9
ovarian cancer 8492 4.60660111515514E-9
pilocytic astrocytoma 3086 4.96905135210841E-9
osteosarcoma 7933 2.99490961905679E-6
group 4 medulloblastoma 1875 2.7047525292235E-5
psoriasis 6685 4.60810904641475E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 7.34374719496428E-5
atypical teratoid / rhabdoid tumor 4369 8.24586213807787E-5
primary pancreatic ductal adenocarcinoma 1271 9.76180716391316E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.21357215038584E-4
invasive ductal carcinoma 2950 4.10624229258909E-4
pancreatic cancer 2300 8.11207005712142E-4
pancreatic carcinoma 567 0.00103689898897895
ductal carcinoma in situ 1745 0.0022018164299819
tuberculosis 1563 0.00228741910871622
Atopic dermatitis 944 0.00254610239934885
medulloblastoma, large-cell 6234 0.00256387761683774
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00512803584791342
Polycystic Ovary Syndrome 335 0.0160322993055937
adrenocortical carcinoma 1427 0.0161216830704362
cystic fibrosis 1670 0.0190250695720534
acute myeloid leukemia 785 0.0306548715756961
spina bifida 1064 0.0435677332899902
Disease Target Count Z-score Confidence
Nonsyndromic deafness 121 3.59 1.8
Disease Target Count
Deafness, autosomal recessive, 74 1



Accession Q8IXL7 B4DR19 B7ZAQ0 Q6UXS2 MsrB3
Symbols DFNB74


PANTHER Protein Class (2)

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
C. elegans EggNOG Inparanoid
Fruitfly OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (7)

24583268 MsrB3 deficiency activates the cell cycle inhibitors p21 and p27.
22422452 DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.
22405767 these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis.
22310715 Taken together, these data provide evidence that the ER type of MsrB, MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging.
22027001 Results identified an antimicrobial peptide from the human methionine sulfoxide reductase B3 protein.
21185009 an in vitro assay revealed that p.Cys89Gly completely abolished MSRB3 enzymatic activity and that p.Arg19X is a null allele for MSRB3 mitochondrial isoforms, indicating that DFNB74 deafness might be a mitochondrial disease limited to the inner ear.
20195514 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (26)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24583268 2014 Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways.
23704328 2013 Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
22832960 2012 A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
22504421 2012 Common variants at 12q14 and 12q24 are associated with hippocampal volume.
22422452 2012 DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.
22405767 2012 Methionine sulfoxide reductase B3 protects from endoplasmic reticulum stress in Drosophila and in mammalian cells.
22310715 2012 Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.
22027001 2011 Identification of an antimicrobial peptide from human methionine sulfoxide reductase B3.
21185009 2011 Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.