Tbio PHC2 Polyhomeotic-like protein 2

Protein Summary

Description

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IXK0
• A1L4Q1
• A8KA40
• D3DPR2
• Q2TAL3
• Q5T0C1
• Q6NUJ6
• Q6ZQR1
• Q8N306
• Q8TAG8
• Q96BL4
• Q9Y4Y7
• hPH2

Gene Name

• PHC2

Ensembl ID

• ENST00000257118
• ENSP00000257118
• ENSG00000134686
• ENST00000373418
• ENSP00000362517

Symbol

• EDR2
• PH2
• PH2
• EDR2
• HPH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
transcription factor perturbation	0.8
virus perturbation	0.79
PubMedID	0.77
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Polyhomeotic-like Protein 2

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Polyhomeotic-like Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Polyhomeotic-like Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.4   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.4   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0