| Tbio | Mitochondrial Rho GTPase 2 |
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Comments
Property Summary
| NCBI Gene PubMed Count | 19 |
| Grant Count | 28 |
| R01 Count | 5 |
| Funding | $5,508,011.54 |
| PubMed Score | 19.78 |
| PubTator Score | 11.96 |
| PMID | Text |
|---|---|
| 26259702 | Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. |
| 24256248 | The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration. |
| 22078885 | Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway. |
| 20877624 | Observational study of gene-disease association. (HuGE Navigator) |
| 19098100 | Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria. |
| 16630562 | Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules. |
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELRE 1 - 70 EIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPE 71 - 140 IETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELN 141 - 210 AFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDAL 211 - 280 ELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVR 281 - 350 TEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCK 351 - 420 VVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVAC 421 - 490 LMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPA 491 - 560 EPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ 561 - 618 //
| PMID | Year | Title |
|---|---|---|
| 26259702 | 2015 | Mitotic redistribution of the mitochondrial network by Miro and Cenp-F. |
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 24995978 | 2014 | Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. |
| 24256248 | 2013 | Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins. |
| 23446634 | 2013 | Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 22078885 | 2011 | PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. |
| More... |
