FBXO16
F-box only protein 16
Protein Summary
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000380254
- ENSP00000369604
- ENSG00000214050
- ENST00000518734
- ENSP00000429687
- FBX16
- FBX16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.64 | ||
tissue sample | 0.64 | ||
transcription factor binding site profile | 0.61 | ||
PubMedID | 0.54 | ||
cellular component | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.23 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 109 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.23 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 109 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0