Property Summary

NCBI Gene PubMed Count 13
PubMed Score 46.51
PubTator Score 20.51

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 2.99655284257373E-28
ovarian cancer 8492 3.17511686193672E-13
chronic lymphosyte leukemia 232 3.59724366841199E-10
Duchenne muscular dystrophy 602 1.82954913425473E-7
tuberculosis 1563 3.31354472045226E-6
pilocytic astrocytoma 3086 3.72787762331024E-6
lung cancer 4473 5.63730150907063E-6
medulloblastoma, large-cell 6234 6.874364544802E-6
group 4 medulloblastoma 1875 2.00673203589011E-5
malignant mesothelioma 3163 4.28538577931337E-5
lung adenocarcinoma 2714 5.75708924903428E-5
adrenocortical carcinoma 1427 7.61893374505632E-5
invasive ductal carcinoma 2950 8.55405852016321E-5
breast carcinoma 1614 1.55393413098016E-4
Breast cancer 3099 1.58804967672265E-4
psoriasis 6685 3.53293083980956E-4
ductal carcinoma in situ 1745 6.20206314537396E-4
Atopic dermatitis 944 0.00174483881350223
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00210982684093026
glioblastoma 5572 0.0021700802551452
Down syndrome 548 0.00285588577395057
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00517233709547554
atypical teratoid / rhabdoid tumor 4369 0.0145357069671101
colon cancer 1475 0.018908457567298
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0231095960731473
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0243931714186385
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0250417326363044
fibroadenoma 557 0.0411618129638856
astrocytoma 1493 0.0487947229510225



Accession Q8IX05 A8K5G4 B4E2T9 Q15009
Symbols DCL1


  Ortholog (5)

Species Source
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

Pathway (1)

Gene RIF (6)

23383108 A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD302 (DCL1) in peptide-treated PBMCs
20861185 Decreased DCL1 is associated with angiogenesis in prostate cancer.
20237496 Observational study of gene-disease association. (HuGE Navigator)
19317456 DCL1 equilibrium unfolding is characterized at the amino acid level.
17947679 hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration
12824192 Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1

AA Sequence

SPYNEDCVLVVGEENEYPVQFD                                                    211 - 232

Text Mined References (14)

PMID Year Title
20861185 2010 DLC1 negatively regulates angiogenesis in a paracrine fashion.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19946888 2010 Defining the membrane proteome of NK cells.
19317456 2009 Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.
17947679 2007 The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12824192 2003 Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1.