ARHGAP12
Rho GTPase-activating protein 12
Protein Summary
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- ENST00000311380
- ENSP00000310984
- ENSG00000165322
- ENST00000344936
- ENSP00000345808
- ENST00000375250
- ENSP00000364399
- ENST00000396144
- ENSP00000379448
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
cell type or tissue | 0.92 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.91 | ||
transcription factor perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.76 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 44 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.76 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 44 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0