Protein Summary
May regulate IL2 production by T-cells. May be involved in neuron regeneration. This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]
- ENST00000397909
- ENSP00000381007
- ENSG00000067798
- ENST00000536525
- ENSP00000446132
- KIAA0938
- POMFIL1
- STEERIN3
- POMFIL1
- unc53H3
- STEERIN3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 0.93 | ||
virus perturbation | 0.9 | ||
transcription factor perturbation | 0.74 | ||
gene perturbation | 0.73 | ||
phenotype | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.45 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.45 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0