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  8. Mitogen-activated protein kinase kinase kinase kinase 3

Tchem Mitogen-activated protein kinase kinase kinase kinase 3

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

 Comments

Property Summary

Ligand Count 7
NCBI Gene PubMed Count 23
PubMed Score 15.30
PubTator Score 16.91

Knowledge Summary

Patent (20,135)

TINX Plot

  Disease (4)

Disease Target Count P-value
lung cancer 4740 3.2e-05
osteosarcoma 7950 7.8e-03
ovarian cancer 8520 8.5e-03
ependymoma 4679 3.0e-02
intraductal papillary-mucinous neoplasm (IPMN) 3291 3.1e-02
Multiple myeloma 1332 4.5e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.6
Disease Target Count Z-score Confidence
adult-onset Still's disease 8 3.507 1.8

Expression

  Differential Expression (6)

Disease log2 FC p
ependymoma 1.100 3.0e-02
intraductal papillary-mucinous neoplasm ... 1.700 3.1e-02
lung cancer 1.700 3.2e-05
Multiple myeloma 1.578 4.5e-02
osteosarcoma 1.115 7.8e-03
ovarian cancer -1.200 8.5e-03

Synonym

Accession Q8IVH8 Q6IQ39 Q8IVH7 Q9UDM5 Q9Y6R5
Symbols GLK
MEKKK3
MEKKK 3
MAPKKKK3
RAB8IPL1

Gene

MAP4K3

  Ortholog (12)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA
Inparanoid OMA
OMA EggNOG

 UniProt Keyword (12)

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 GO Function (4)

 GO Component (1)

 GO Process (7)

 Compartment GO Term (9)

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

See all...

Pathway (11)

See all...

Protein-protein Interaction (1)

MAP4K5  

PDB (1)

Drug (1)

Structure of neratinib

neratinib
pKd 8.11

Ligand (6)

Structure of bosutinib

bosutinib
pKd 8.29

Structure of neratinib

neratinib
pKd 8.11

Structure of CHEMBL2086760

CHEMBL2086760
pIC50 7.60

Structure of CHEMBL388978

CHEMBL388978
pKd 8.09

Structure of CHEMBL288441

CHEMBL288441
pKd 8.29

Structure of compound 8h [PMID: 22765894]

compound 8h [PMID: 22765894]
pIC50 7.60

Gene RIF (13)

AA Sequence 

MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH      1 - 70
PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGA     71 - 140
NILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAEL    141 - 210
QPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRS    211 - 280
LAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHH    281 - 350
ELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD    351 - 420
ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVA    421 - 490
LGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIH    491 - 560
CASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLP    561 - 630
GLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLE    631 - 700
WVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESD    701 - 770
TPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG    771 - 840
RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY                    841 - 894
//

Text Mined References (28)

PMID Year Title