Tchem MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3

Protein Summary

Description

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q8IVH8
• Q6IQ39
• Q8IVH7
• Q9UDM5
• Q9Y6R5

Gene Name

• MAP4K3

Ensembl ID

• ENST00000263881
• ENSP00000263881
• ENSG00000011566
• ENST00000341681
• ENSP00000345434

Symbol

• RAB8IPL1
• GLK
• MEKKK3
• MEKKK 3
• MAPKKKK3
• RAB8IPL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
protein domain	0.85
transcription factor binding site profile	0.8
histone modification site profile	0.75
cell type or tissue	0.67

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Khs Subfamily / Mitogen-activated Protein Kinase Kinase Kinase Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2