| Tchem | Mitogen-activated protein kinase kinase kinase kinase 3 |
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung cancer | 4740 | 3.2e-05 |
| osteosarcoma | 7950 | 7.8e-03 |
| ovarian cancer | 8520 | 8.5e-03 |
| ependymoma | 4679 | 3.0e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.1e-02 |
| Multiple myeloma | 1332 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| adult-onset Still's disease | 8 | 3.507 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | 1.100 | 3.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.700 | 3.1e-02 |
| lung cancer | 1.700 | 3.2e-05 |
| Multiple myeloma | 1.578 | 4.5e-02 |
| osteosarcoma | 1.115 | 7.8e-03 |
| ovarian cancer | -1.200 | 8.5e-03 |
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 1 - 70 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGA 71 - 140 NILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAEL 141 - 210 QPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRS 211 - 280 LAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHH 281 - 350 ELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD 351 - 420 ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVA 421 - 490 LGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIH 491 - 560 CASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLP 561 - 630 GLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLE 631 - 700 WVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESD 701 - 770 TPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG 771 - 840 RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 841 - 894 //
