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Tbio
PLD3
Phospholipase D3

Protein Summary
Description
May be involved in APP processing. This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356508
  • ENSP00000348901
  • ENSG00000105223
  • ENST00000409281
  • ENSP00000387022
  • ENST00000409419
  • ENSP00000386293
  • ENST00000409587
  • ENSP00000387050
  • ENST00000409735
  • ENSP00000386938

Symbol
  • AD19
  • HUK4
  • HU-K4
  • SCA46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
histone modification site profile
0.87
transcription factor perturbation
0.84
disease perturbation
0.79
small molecule perturbation
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.1   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.1   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0