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Tbio
CLEC10A
C-type lectin domain family 10 member A

Protein Summary
Description
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254868
  • ENSP00000254868
  • ENSG00000132514
  • ENST00000571664
  • ENSP00000460252
  • ENST00000576617
  • ENSP00000458728

Symbol
  • CLECSF13
  • CLECSF14
  • HML
  • HML
  • MGL
  • HML2
  • CD301
  • CLECSF13
  • CLECSF14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
disease
0.61
tissue sample
0.59
phenotype
0.56
PubMedID
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.5   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.5   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0