Tbio ERC1 ELKS/Rab6-interacting/CAST family member 1

Protein Summary

Description

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q8IUD2
• A2RU77
• A7E295
• D3DUP7
• D3DUP8
• Q6NVK2
• Q8IUD3
• Q8IUD4
• Q8IUD5
• Q8NAS1
• Q9NXN5
• Q9UIK7
• Q9UPS1
• ERC-1

Gene Name

• ERC1

Ensembl ID

• ENST00000347735
• ENSP00000340054
• ENSG00000082805
• ENST00000360905
• ENSP00000354158
• ENST00000397203
• ENSP00000380386
• ENST00000440394
• ENSP00000410064
• ENST00000543086
• ENSP00000438546
• ENST00000545948
• ENSP00000442976
• ENST00000589028
• ENSP00000468263
• ENST00000611180
• ENSP00000479523
• ENST00000634346
• ENSP00000489059
• ENSG00000283017
• ENST00000634945
• ENSP00000489460
• ENST00000635106
• ENSP00000489601
• ENST00000635345
• ENSP00000489265
• ENST00000635430
• ENSP00000489361
• ENST00000635459
• ENSP00000489064
• ENST00000635644
• ENSP00000489120
• ENST00000635703
• ENSP00000489206

Symbol

• ELKS
• KIAA1081
• RAB6IP2
• ELKS
• Cast2
• ERC-1
• RAB6IP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
transcription factor perturbation	0.96
histone modification site profile	0.88
trait	0.86
microRNA	0.85

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Elks/rab6-interacting/cast Family Member 1

Protein / Enzyme Modulator / G-protein Modulator / Elks/rab6-interacting/cast Family Member 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Elks/rab6-interacting/cast Family Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0