Tchem CAMK1D Calcium/calmodulin-dependent protein kinase type 1D

Protein Summary

Description

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q8IU85
• B0YIY0
• Q9HD31

Gene Name

• CAMK1D

Ensembl ID

• ENST00000378845
• ENSP00000368122
• ENSG00000183049
• ENST00000619168
• ENSP00000478874

Symbol

• CAMKID
• CKLiK
• CaM-K1
• CaMKID

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor perturbation	0.88
trait	0.86
transcription factor binding site profile	0.86
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / ... / Non-receptor Serine/threonine Protein Kinase / Calcium/calmodulin-dependent Protein Kinase Type 1d

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camk1 Family / Calcium/calmodulin-dependent Protein Kinase Type 1d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 404   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1