Tdark ZNF280B Zinc finger protein 280B

Protein Summary

Description

May function as a transcription factor. The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q86YH2

Gene Name

• ZNF280B

Ensembl ID

• ENST00000613655
• ENSP00000481008
• ENSG00000275004
• ENST00000619852
• ENSP00000480958

Symbol

• SUHW2
• ZNF279
• ZNF632
• SUHW2
• ZNF279
• ZNF632
• 5'OY11.1
• D87009.C22.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
microRNA	0.7
tissue sample	0.63
transcription factor binding site profile	0.59
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0