| Tbio | Zinc finger protein DZIP1 |
May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3163 | 6.80245093477316E-7 |
| ovarian cancer | 8492 | 4.60937709994922E-5 |
| medulloblastoma, large-cell | 6234 | 1.28250900118349E-4 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 1.42709982160334E-4 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 1.48250029348028E-4 |
| lung cancer | 4473 | 9.16595019649679E-4 |
| cystic fibrosis | 1670 | 0.00115948538881011 |
| osteosarcoma | 7933 | 0.00132476397894383 |
| Pick disease | 1893 | 0.00145258072280575 |
| group 4 medulloblastoma | 1875 | 0.00161131310205734 |
| psoriasis | 6685 | 0.00239919112857177 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0040029819455639 |
| adult high grade glioma | 2148 | 0.00486238769960966 |
| chronic rhinosinusitis | 512 | 0.0075971993708198 |
| interstitial cystitis | 2299 | 0.00921754794166341 |
| glioblastoma | 5572 | 0.0199430357949382 |
| colon cancer | 1475 | 0.0288173868748079 |
| severe Alzheimer's disease | 49 | 0.0417254934400745 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acrodermatitis enteropathica | 18 | 3.773 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.500 | 0.000 |
| psoriasis | -1.700 | 0.002 |
| osteosarcoma | 1.423 | 0.001 |
| glioblastoma | -1.700 | 0.020 |
| group 4 medulloblastoma | -2.000 | 0.002 |
| medulloblastoma, large-cell | -2.700 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -2.900 | 0.000 |
| intraductal papillary-mucinous carcinoma... | -2.900 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | -2.900 | 0.004 |
| lung cancer | 1.100 | 0.001 |
| colon cancer | -1.200 | 0.029 |
| interstitial cystitis | -1.200 | 0.009 |
| cystic fibrosis | 1.100 | 0.001 |
| adult high grade glioma | -1.300 | 0.005 |
| severe Alzheimer's disease | -1.047 | 0.042 |
| Pick disease | -1.100 | 0.001 |
| ovarian cancer | -2.100 | 0.000 |
| chronic rhinosinusitis | -1.621 | 0.008 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Zebrafish | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 24993635 | The abundance of DZIP1-associated mRNAs increased with treatment. |
| 24072710 | Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. |
| 21878643 | reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling. |
| 15081113 | DZIP may associate with DAZ and its other cofactors in an RNA-binding protein complex that functions in both ES cells and germ cells |
| 15081113 | gene expression profiling [DZIP] |
MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQFRPRLESVDWR 1 - 70 RLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTS 71 - 140 QLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQ 141 - 210 AFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEE 211 - 280 DFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFK 281 - 350 EDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 351 - 420 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGNPLAWQAFESQPAAPAVPMNAPALHTLETKSSLPM 421 - 490 VHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINA 491 - 560 DIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEV 561 - 630 PKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGP 631 - 700 LPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVP 701 - 770 EMFIKKEELQELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG 771 - 840 EGLQENESSTLKSSLVTVTDWSDTSDV 841 - 867 //
| PMID | Year | Title |
|---|---|---|
| 25350695 | 2014 | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. |
| 24993635 | 2014 | Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules. |
| 24072710 | 2013 | Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. |
| 23955340 | 2013 | Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. |
| 21878643 | 2011 | The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. |
| 19852954 | 2010 | The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15081113 | 2004 | Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. |
| More... |
