Tbio | Zinc finger protein DZIP1 |
May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).
Comments
Disease | Target Count | P-value |
---|---|---|
malignant mesothelioma | 3163 | 6.80245093477316E-7 |
ovarian cancer | 8492 | 4.60937709994922E-5 |
medulloblastoma, large-cell | 6234 | 1.28250900118349E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 1.42709982160334E-4 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 1.48250029348028E-4 |
lung cancer | 4473 | 9.16595019649679E-4 |
cystic fibrosis | 1670 | 0.00115948538881011 |
osteosarcoma | 7933 | 0.00132476397894383 |
Pick disease | 1893 | 0.00145258072280575 |
group 4 medulloblastoma | 1875 | 0.00161131310205734 |
psoriasis | 6685 | 0.00239919112857177 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0040029819455639 |
adult high grade glioma | 2148 | 0.00486238769960966 |
chronic rhinosinusitis | 512 | 0.0075971993708198 |
interstitial cystitis | 2299 | 0.00921754794166341 |
glioblastoma | 5572 | 0.0199430357949382 |
colon cancer | 1475 | 0.0288173868748079 |
severe Alzheimer's disease | 49 | 0.0417254934400745 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Acrodermatitis enteropathica | 18 | 3.773 | 1.9 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | -1.500 | 0.000 |
psoriasis | -1.700 | 0.002 |
osteosarcoma | 1.423 | 0.001 |
glioblastoma | -1.700 | 0.020 |
group 4 medulloblastoma | -2.000 | 0.002 |
medulloblastoma, large-cell | -2.700 | 0.000 |
intraductal papillary-mucinous adenoma (... | -2.900 | 0.000 |
intraductal papillary-mucinous carcinoma... | -2.900 | 0.000 |
intraductal papillary-mucinous neoplasm ... | -2.900 | 0.004 |
lung cancer | 1.100 | 0.001 |
colon cancer | -1.200 | 0.029 |
interstitial cystitis | -1.200 | 0.009 |
cystic fibrosis | 1.100 | 0.001 |
adult high grade glioma | -1.300 | 0.005 |
severe Alzheimer's disease | -1.047 | 0.042 |
Pick disease | -1.100 | 0.001 |
ovarian cancer | -2.100 | 0.000 |
chronic rhinosinusitis | -1.621 | 0.008 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Zebrafish | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
24993635 | The abundance of DZIP1-associated mRNAs increased with treatment. |
24072710 | Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. |
21878643 | reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling. |
15081113 | DZIP may associate with DAZ and its other cofactors in an RNA-binding protein complex that functions in both ES cells and germ cells |
15081113 | gene expression profiling [DZIP] |
MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQFRPRLESVDWR 1 - 70 RLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTS 71 - 140 QLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQ 141 - 210 AFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEE 211 - 280 DFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFK 281 - 350 EDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 351 - 420 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGNPLAWQAFESQPAAPAVPMNAPALHTLETKSSLPM 421 - 490 VHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINA 491 - 560 DIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEV 561 - 630 PKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGP 631 - 700 LPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVP 701 - 770 EMFIKKEELQELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG 771 - 840 EGLQENESSTLKSSLVTVTDWSDTSDV 841 - 867 //
PMID | Year | Title |
---|---|---|
25350695 | 2014 | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. |
24993635 | 2014 | Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules. |
24072710 | 2013 | Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. |
23955340 | 2013 | Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. |
21878643 | 2011 | The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. |
19852954 | 2010 | The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15081113 | 2004 | Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. |
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