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  6. Kinesin-like protein KIF18B

Tdark Kinesin-like protein KIF18B

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 4.73
PubTator Score 4.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
psoriasis 6685 5.09637569916983E-70
non-small cell lung cancer 2798 1.51009970935463E-23
glioblastoma 5572 3.5032293290372E-9
atypical teratoid/rhabdoid tumor 1095 2.49160167886128E-8
Breast cancer 3099 3.0951817819064E-8
group 3 medulloblastoma 2254 4.55698848321768E-8
pilocytic astrocytoma 3086 8.06378822914527E-8
lung adenocarcinoma 2714 9.23292329519044E-8
pediatric high grade glioma 2712 6.00165574572723E-7
malignant mesothelioma 3163 7.21651359504303E-7
lung cancer 4473 2.22942899039931E-6
Atopic dermatitis 944 1.2072255343909E-5
nasopharyngeal carcinoma 1056 4.68008459866007E-5
ovarian cancer 8492 2.40258893165986E-4
medulloblastoma, large-cell 6234 4.72356685826199E-4
posterior fossa group A ependymoma 1511 5.14858680020183E-4
primitive neuroectodermal tumor 3031 5.88157727229963E-4
osteosarcoma 7933 9.59188402196911E-4
colon cancer 1475 0.00215485817258497
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00265701062918528
invasive ductal carcinoma 2950 0.00539126670631091
Endometriosis 535 0.0213246450332529

Expression

  Differential Expression (22)

Disease log2 FC p
malignant mesothelioma 1.500 0.000
glioblastoma 2.200 0.000
osteosarcoma -2.858 0.001
group 3 medulloblastoma 3.700 0.000
atypical teratoid/rhabdoid tumor 1.900 0.000
medulloblastoma, large-cell 2.000 0.000
primitive neuroectodermal tumor 2.100 0.001
Atopic dermatitis 2.100 0.000
non-small cell lung cancer 1.727 0.000
intraductal papillary-mucinous carcinoma... 1.100 0.003
colon cancer 2.400 0.002
lung cancer 4.000 0.000
pediatric high grade glioma 2.000 0.000
pilocytic astrocytoma 1.800 0.000
posterior fossa group A ependymoma 1.300 0.001
psoriasis 1.500 0.000
lung adenocarcinoma 1.500 0.000
nasopharyngeal carcinoma 1.200 0.000
Endometriosis 1.594 0.021
Breast cancer 2.200 0.000
invasive ductal carcinoma 1.600 0.005
ovarian cancer 1.400 0.000

Synonym

Accession Q86Y91 A6NJI2 B7ZM49 B9EGM8 D5L6I1
Symbols

Gene

KIF18B

PANTHER Protein Class (3)

  Ortholog (8)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid

 GO Function (4)

 GO Component (6)

 GO Process (6)

 Compartment GO Term (35)

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 HCA RNA Cell Line (56)

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Pathway (9)

 UniProt Keyword (16)

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Gene RIF (5)

PMID Text
26150501 Kif18B is only modestly processive and that the motor switches frequently between directed and diffusive modes of motility.
25236463 High KIF18B expression is associated with neoplasms.
21820309 Results uncover a novel role for Aurora A/B kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells.
21737685 Kif18B is a new microtubule dynamics regulatory protein that interacts with EB1 to control astral microtubule length
20600703 the expression of KIF18B is regulated in a cell cycle-dependent manner and therefore may play an important role(s) in cell division.

AA Sequence 

MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGP      1 - 70
KKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYL     71 - 140
TTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLE    141 - 210
ILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERL    211 - 280
REGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNT    281 - 350
LKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP    351 - 420
EHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMP    421 - 490
EQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETL    491 - 560
QQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPA    561 - 630
QGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPR    631 - 700
VCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIP    701 - 770
RAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSN    771 - 840
RRNGKDLIRVGRALSAGNGVTKVS                                                  841 - 864
//

Text Mined References (16)

PMID Year Title
26150501 2015 Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.
25236463 2015 Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21820309 2011 A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
21737685 2011 Kif18B interacts with EB1 and controls astral microtubule length during mitosis.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20600703 2010 Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
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