| Tdark | Kinesin-like protein KIF18B |
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Comments
Property Summary
| NCBI Gene PubMed Count | 8 |
| Grant Count | 4 |
| R01 Count | 4 |
| Funding | $282,052.25 |
| PubMed Score | 4.73 |
| PubTator Score | 4.83 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.500 | 0.000 |
| glioblastoma | 2.200 | 0.000 |
| osteosarcoma | -2.858 | 0.001 |
| group 3 medulloblastoma | 3.700 | 0.000 |
| atypical teratoid/rhabdoid tumor | 1.900 | 0.000 |
| medulloblastoma, large-cell | 2.000 | 0.000 |
| primitive neuroectodermal tumor | 2.100 | 0.001 |
| Atopic dermatitis | 2.100 | 0.000 |
| non-small cell lung cancer | 1.727 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 0.003 |
| colon cancer | 2.400 | 0.002 |
| lung cancer | 4.000 | 0.000 |
| pediatric high grade glioma | 2.000 | 0.000 |
| pilocytic astrocytoma | 1.800 | 0.000 |
| posterior fossa group A ependymoma | 1.300 | 0.001 |
| psoriasis | 1.500 | 0.000 |
| lung adenocarcinoma | 1.500 | 0.000 |
| nasopharyngeal carcinoma | 1.200 | 0.000 |
| Endometriosis | 1.594 | 0.021 |
| Breast cancer | 2.200 | 0.000 |
| invasive ductal carcinoma | 1.600 | 0.005 |
| ovarian cancer | 1.400 | 0.000 |
| PMID | Text |
|---|---|
| 26150501 | Kif18B is only modestly processive and that the motor switches frequently between directed and diffusive modes of motility. |
| 25236463 | High KIF18B expression is associated with neoplasms. |
| 21820309 | Results uncover a novel role for Aurora A/B kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells. |
| 21737685 | Kif18B is a new microtubule dynamics regulatory protein that interacts with EB1 to control astral microtubule length |
| 20600703 | the expression of KIF18B is regulated in a cell cycle-dependent manner and therefore may play an important role(s) in cell division. |
MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGP 1 - 70 KKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYL 71 - 140 TTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLE 141 - 210 ILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERL 211 - 280 REGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNT 281 - 350 LKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP 351 - 420 EHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMP 421 - 490 EQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETL 491 - 560 QQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPA 561 - 630 QGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPR 631 - 700 VCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIP 701 - 770 RAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSN 771 - 840 RRNGKDLIRVGRALSAGNGVTKVS 841 - 864 //
| PMID | Year | Title |
|---|---|---|
| 26150501 | 2015 | Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8. |
| 25236463 | 2015 | Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21820309 | 2011 | A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. |
| 21737685 | 2011 | Kif18B interacts with EB1 and controls astral microtubule length during mitosis. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 20600703 | 2010 | Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 18691976 | 2008 | Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| More... |
