| Tbio | Kinesin-like protein KIF18B |
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.6e-36 |
| non-small cell lung cancer | 2890 | 1.5e-23 |
| Breast cancer | 3578 | 4.2e-17 |
| glioblastoma | 5792 | 3.5e-09 |
| group 3 medulloblastoma | 4104 | 4.6e-08 |
| lung adenocarcinoma | 2716 | 9.2e-08 |
| Astrocytoma, Pilocytic | 3081 | 3.2e-07 |
| malignant mesothelioma | 3232 | 7.2e-07 |
| lung cancer | 4740 | 3.9e-06 |
| Atopic dermatitis | 952 | 1.2e-05 |
| nasopharyngeal carcinoma | 1058 | 4.7e-05 |
| ovarian cancer | 8520 | 2.4e-04 |
| medulloblastoma, large-cell | 6241 | 4.7e-04 |
| posterior fossa group A ependymoma | 468 | 5.1e-04 |
| primitive neuroectodermal tumor | 3035 | 5.9e-04 |
| osteosarcoma | 7950 | 9.6e-04 |
| adult high grade glioma | 3801 | 1.0e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.7e-03 |
| invasive ductal carcinoma | 2951 | 5.4e-03 |
| colon cancer | 1478 | 1.2e-02 |
| Endometriosis | 540 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.600 | 1.0e-03 |
| Astrocytoma, Pilocytic | 1.700 | 3.2e-07 |
| Atopic dermatitis | 2.100 | 1.2e-05 |
| atypical teratoid / rhabdoid tumor | 1.200 | 2.3e-03 |
| Breast cancer | 2.100 | 4.2e-17 |
| colon cancer | 1.800 | 1.2e-02 |
| Endometriosis | 1.594 | 2.1e-02 |
| glioblastoma | 2.200 | 3.5e-09 |
| group 3 medulloblastoma | 3.700 | 4.6e-08 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 2.7e-03 |
| invasive ductal carcinoma | 1.600 | 5.4e-03 |
| lung adenocarcinoma | 1.500 | 9.2e-08 |
| lung cancer | 3.900 | 3.9e-06 |
| malignant mesothelioma | 1.500 | 7.2e-07 |
| medulloblastoma, large-cell | 2.000 | 4.7e-04 |
| nasopharyngeal carcinoma | 1.200 | 4.7e-05 |
| non-small cell lung cancer | 1.727 | 1.5e-23 |
| osteosarcoma | -2.858 | 9.6e-04 |
| ovarian cancer | 1.400 | 2.4e-04 |
| posterior fossa group A ependymoma | 1.300 | 5.1e-04 |
| primitive neuroectodermal tumor | 2.100 | 5.9e-04 |
| psoriasis | 1.100 | 3.6e-36 |
MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGP 1 - 70 KKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYL 71 - 140 TTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLE 141 - 210 ILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERL 211 - 280 REGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNT 281 - 350 LKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP 351 - 420 EHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMP 421 - 490 EQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETL 491 - 560 QQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPA 561 - 630 QGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPR 631 - 700 VCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIP 701 - 770 RAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSN 771 - 840 RRNGKDLIRVGRALSAGNGVTKVS 841 - 864 //
