Tbio GKN2 Gastrokine-2

Protein Summary

Description

The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q86XP6
• Q6UWS6

Gene Name

• GKN2

Ensembl ID

• ENST00000328895
• ENSP00000329292
• ENSG00000183607

Symbol

• BLOT
• GDDR
• TFIZ1
• GDDR
• TFIZ1
• PRO813
• BRICD1B
• VLTI465

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.92
cell line	0.6
tissue sample	0.45
biological term	0.39
tissue	0.36

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.5   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.5   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0