Tbio CHSY1 Chondroitin sulfate synthase 1

Protein Summary

Description

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q86X52
• Q6UX38
• Q7LFU5
• Q9Y2J5

Gene Name

• CHSY1

Ensembl ID

• ENST00000254190
• ENSP00000254190
• ENSG00000131873

Symbol

• CHSY
• CSS1
• KIAA0990
• CHSY
• CSS1
• TPBS
• ChSy-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
kinase perturbation	0.84
disease perturbation	0.83
microRNA	0.68
pathway	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.13   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.13   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0