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Tbio Ral GTPase-activating protein subunit beta

Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 102.37
PubTator Score 1.98

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.5
Disease Target Count Z-score Confidence
Cancer 2499 3.345 1.7
Chickenpox 8 3.225 1.6

Expression

  Differential Expression (4)

Disease log2 FC p
intraductal papillary-mucinous carcinoma... 1.100 3.8e-04
intraductal papillary-mucinous neoplasm ... 1.300 1.3e-03
osteosarcoma -1.194 3.9e-05
ovarian cancer 1.100 4.1e-03

Synonym

Accession Q86X10 A2A2E8 A2A2E9 Q5TG31 Q8N3D1 Q8WWC0 Q9H3X8 Q9UJR1 Q9ULK1 Q9Y3G9
Symbols KIAA1219
RalGAPbeta

Gene

RALGAPB

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (5)

 GO Function (2)

 GO Process (2)

 Compartment GO Term (4)

 IMPC Phenotype (2)

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

Protein-protein Interaction (1)

RALGAPA2  

Gene RIF (1)

AA Sequence 

MYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVI      1 - 70
CYGLTLPLDGETVKYCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRL     71 - 140
CLQVLRAIQKLARESSLMARETWEVLLLFLLQINDILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRC    141 - 210
FPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPDEDASLIPPEMDNECVA    211 - 280
QTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFL    281 - 350
GISRPRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLS    351 - 420
SPNQTSSEPRPLPAPRRPKVNSILNLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMS    421 - 490
TDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEILPAYLSRFYMLLIQGLQINDYVCHPVL    491 - 560
ASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPLPHHFGT    561 - 630
VKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIG    631 - 700
CQMEMGGGENNLKSHSRTNSGISSASGGSTEPTTPDSERPAQALLRDYALNTDSAAGLLIRSIHLVTQRL    701 - 770
NSQWRQDMSISLAALELLSGLAKVKVMVDSGDRKRAISSVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCL    771 - 840
CVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMRVKDAAEATLTCIMQLL    841 - 910
GAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRG    911 - 980
MSGRLAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEI    981 - 1050
VTEELEERHEKLRSGMAQQIAYEIHLEQQSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSL   1051 - 1120
EALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYMKPGQKTNQEILKNVESSRTVQP   1121 - 1190
HFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQEVISSEDIGASIFNGQKKVLYYADALTE   1191 - 1260
IAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPSLTLELFPNHTDNLNSSQRLSPSSRMRKLPQ   1261 - 1330
GRPVPPLGPETRVSVVWVERYDDIENFPLSELMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTG   1331 - 1400
LFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTVINICRRKRLESDSYSPPHVRRKQKITDIVNKY   1401 - 1470
RNKQLEPEFYTSLFQEVGLKNCSS                                                 1471 - 1494
//

Text Mined References (18)

PMID Year Title