Tdark COA5 Cytochrome c oxidase assembly factor 5

Protein Summary

Description

Involved in an early step of the mitochondrial complex IV assembly process. This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q86WW8

Gene Name

• COA5

Ensembl ID

• ENST00000328709
• ENSP00000330730
• ENSG00000183513

Symbol

• C2orf64
• Pet191
• C2orf64
• CEMCOX3
• 6330578E17Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
histone modification site profile	0.89
transcription factor perturbation	0.8
small molecule perturbation	0.73
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.89   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.89   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0