Property Summary

NCBI Gene PubMed Count 15
PubMed Score 0.00
PubTator Score 7.28

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
lung carcinoma 2844 3.99366680832803E-37
non-small cell lung cancer 2798 3.74699549979028E-16
ovarian cancer 8492 1.037430566984E-9
lung adenocarcinoma 2714 1.1687434596802E-9
pituitary cancer 1972 1.88700350705858E-4
Pick disease 1893 2.27436317685781E-4
osteosarcoma 7933 6.28571778335403E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00433126370482935
gastric cancer 436 0.00591937370385294
primary pancreatic ductal adenocarcinoma 1271 0.00868158604132847
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0136494171269041
astrocytic glioma 2241 0.0138431655585726
subependymal giant cell astrocytoma 2287 0.0180291811350065
pancreatic cancer 2300 0.0187114703905524
pancreatic carcinoma 567 0.0187114703905524
group 4 medulloblastoma 1875 0.0238518120930189
ependymoma 2514 0.0252659265691028
oligodendroglioma 2849 0.0295270512286678

Expression

  Differential Expression (18)

Synonym

Accession Q86WH2 Q86WH1
Symbols RASSF5

Gene

PANTHER Protein Class (2)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG
Cow OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid

Gene RIF (7)

PMID Text
24295637 Taken together, these findings indicate that the RASSF3 promoter rs6581580 T>G SNP is potentially functional, modulating susceptibility to SCCHN among non-Hispanic whites.
24246507 low expression is associated with malignant phenotypes in non-small cell lung cancer patients
23555615 hypermethylation-induced RASSF3 silencing plays an important role in the tumorigenesis of pituitary somatotroph adenomas.
22593196 tumor suppressor activity of RASSF3, which occurs through p53 stabilization and regulation of apoptosis and the cell cycle.
20237496 Observational study of gene-disease association. (HuGE Navigator)
19148488 Mammary tumor incidence in bi-transgenic mice is delayed, suggesting that transgenic Rassf3 may influence mammary tumor incidence in transgenic mice
11965544 The presence of a Ras association domain common to NORE1,RASSF1, and RASSF3 suggests their possible involvement inRas-like signaling pathways.

AA Sequence

MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLK      1 - 70
MTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAK     71 - 140
FALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEED    141 - 210
EQLQNLKRRYTAYRQKLEEALREVWKPD                                              211 - 238
//

Text Mined References (16)

PMID Year Title
24366813 2013 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
24295637 2014 Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck.
24255178 2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
24246507 2014 RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.
23555615 2013 Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas.
23455922 2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
22593196 2012 The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.
20920251 2010 Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19369195 2009 Large-scale proteomics analysis of the human kinome.
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