Tchem PARG Poly(ADP-ribose) glycohydrolase

Protein Summary

Description

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q86W56
• A5YBK3
• B2RC24
• B4DIU5
• B4DYR4
• I6RUV3
• Q6E4P6
• Q6E4P7
• Q7Z742
• Q9Y4W7

Gene Name

• PARG

Ensembl ID

• ENST00000402038
• ENSP00000384408
• ENSG00000227345
• ENST00000616448
• ENSP00000484285

Symbol

• PARG99

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
cell type or tissue	0.7
virus perturbation	0.68
small molecule perturbation	0.66
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Hydrolase / Glycosidase / Poly(adp-ribose) Glycohydrolase

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Poly(adp-ribose) Glycohydrolase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.18   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.18   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0