Property Summary

NCBI Gene PubMed Count 17
PubMed Score 0.00
PubTator Score 7.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Polycystic Ovary Syndrome 335
Disease Target Count P-value
Amyotrophic Lateral Sclerosis 432 3.52920130956522E-7
Multiple Sclerosis 498 4.11034587389394E-6
acute quadriplegic myopathy 1157 2.64637411530871E-4
ovarian cancer 8492 8.8903377390994E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00130669559955207
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00259843397907778
Rheumatoid Arthritis 1171 0.00369434552148693
primary pancreatic ductal adenocarcinoma 1271 0.00759716889558569
active ulcerative colitis 477 0.0153630737656651
non primary Sjogren syndrome sicca 840 0.0280430316000047
Breast cancer 3099 0.0336050488586558
spina bifida 1064 0.035817889435841

Expression

Synonym

Accession Q86VS8 D3DSY8 Q8NBH0 Q9BY13 h-hook3
Symbols HK3

Gene

PDB

5J8E  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
Fruitfly OMA EggNOG

Pathway (1)

Gene RIF (6)

PMID Text
26230842 results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays
25799409 Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease.
20152126 Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1.
17639057 A fusion product between exon 11 of HOOK3 and exon 12 of RET gene was identified by 5'RACE, and the presence of chimeric HOOK3-RET protein of 88 kDa was detected by western blot analysis with an anti-RET antibody.
17237231 Hook3 interacts with a cytoplasmic domain of scavenger receptor A
12950921 Salmonella SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking.

AA Sequence

MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWR      1 - 70
LKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIM     71 - 140
MMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQ    141 - 210
EEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS    211 - 280
ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQN    281 - 350
TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL    351 - 420
KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA    421 - 490
LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANN    491 - 560
ELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEI    561 - 630
QALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQ    631 - 700
ATSSRRSYPGHVQPATAR                                                        701 - 718
//

Text Mined References (25)

PMID Year Title
26230842 2015 High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.
25799409 2015 Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21269460 2011 Initial characterization of the human central proteome.
20152126 2010 Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18799622 2008 An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
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