Tbio FJX1 Four-jointed box protein 1

Protein Summary

Description

Acts as an inhibitor of dendrite extension and branching. The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86VR8
• B2RCA9
• Q9UGK6

Gene Name

• FJX1

Ensembl ID

• ENST00000317811
• ENSP00000400223
• ENSG00000179431

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
kinase perturbation	0.88
PubMedID	0.85
transcription factor binding site profile	0.76
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0