| Tbio | Vacuolar protein-sorting-associated protein 36 |
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.0e-21 |
| Breast cancer | 3578 | 1.1e-11 |
| ependymoma | 4679 | 6.0e-08 |
| ovarian cancer | 8520 | 1.3e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.3e-07 |
| glioblastoma | 5792 | 7.8e-06 |
| adult high grade glioma | 3801 | 1.8e-05 |
| Pick disease | 1894 | 6.2e-05 |
| astrocytic glioma | 2597 | 2.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Kaposi's sarcoma | 22 | 3.078 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.600 | 1.8e-05 |
| astrocytic glioma | -1.300 | 2.9e-02 |
| atypical teratoid / rhabdoid tumor | -1.500 | 3.3e-07 |
| Breast cancer | -1.200 | 1.1e-11 |
| ependymoma | -1.200 | 6.0e-08 |
| glioblastoma | -1.300 | 7.8e-06 |
| non-small cell lung cancer | -1.134 | 4.0e-21 |
| ovarian cancer | -1.800 | 1.3e-07 |
| Pick disease | -1.600 | 6.2e-05 |
MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMAILLSQIVFIE 1 - 70 EQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQSL 71 - 140 QTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKDKQGDIT 141 - 210 EDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGME 211 - 280 LLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSV 281 - 350 LLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS 351 - 386 //
