Tchem SLC47A2 Multidrug and toxin extrusion protein 2

Protein Summary

Description

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86VL8
• A0JBX9
• A0P8Z7
• Q63HJ9
• Q8IV44
• Q96NA1
• MATE-2

Gene Name

• SLC47A2

Ensembl ID

• ENST00000325411
• ENSP00000326671
• ENSG00000180638
• ENST00000350657
• ENSP00000338084
• ENST00000574239
• ENSP00000458694

Symbol

• MATE2
• MATE2
• MATE2K
• MATE2-B
• MATE2-K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
tissue sample	0.67
chemical	0.45
cell line	0.41
cellular component	0.4

Protein Classes

PANTHER Classes

Protein / Transporter / Multidrug And Toxin Extrusion Protein 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc47 Family Of Multidrug And Toxin Extrusion Transporters / Multidrug And Toxin Extrusion Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.17   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.17   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6