Tchem PIM3 Serine/threonine-protein kinase pim-3

Protein Summary

Description

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q86V86
• A5D8X8
• A8K7J0
• B1B0P0
• Q68BM2

Gene Name

• PIM3

Ensembl ID

• ENST00000360612
• ENSP00000353824
• ENSG00000198355

Symbol

• pim-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
small molecule perturbation	0.95
transcription factor binding site profile	0.92
molecular function	0.91
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pim-3

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pim-3

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Pim Family / Serine/threonine-protein Kinase Pim-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.58   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.58   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 948

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1